Product Information

What is Resveratrol?

Resveratrol is a polyphenolic antioxidant that was first isolated from white hellebore by Takaoka in 1940. Chemically known as trihydroxystilbene, it is a non-flavonoid polyphenol compound. In plants, resveratrol is an autoprotective factor produced when plants are stimulated; In addition, resveratrol is naturally found in a variety of foods, such as blueberries, peanuts, mulberries, and grapes (wine).

Most current supplements containing resveratrol are made from Polygonum cuspidatum plant root extract. Resveratrol is generally divided into cis and trans isomers, but trans is more stable (trans-resveratrol is the most common in nature), and many effects are only seen in trans (such as regulating inflammatory pathways and anti-proliferation), so it has become the mainstream of health care ingredients at present, and it is also the main research target.

What are the functions of Resveratrol?

【Main function】

Resveratrol is a natural antioxidant that can reduce blood viscosity, inhibit platelet clotting and vasodilation, keep blood unblocked, prevent the occurrence and development of cancer, and have anti-atherosclerosis and coronary heart disease, ischemic heart disease, and hyperlipidemia.　The tumor-inhibiting effect also has an estrogen-like effect and can be used to treat diseases such as breast cancer.　　

【other functions】

1. Anti-aging activity

Resveratrol protects against oxidative stress through a variety of redox-related molecular pathways (Figure 3). In addition, studies have shown that chromosome integrity is disrupted as humans age, and resveratrol can activate sirtuin, a protein that repairs chromosomal health, thereby slowing down aging.

2. Anti-inflammatory, antibacterial activity

Resveratrol regulates pro-inflammatory factors, anti-inflammatory factors, and chemokines to reduce inflammation. In addition, resveratrol has inhibitory effects on Staphylococcus aureus, catarrhalis, Escherichia coli, Pseudomonas aeruginosa, and has strong inhibitory effects on orphan viruses, herpes simplex viruses and enteroviruses, and coxsackie A and B viruses.

3. Immunomodulatory effects

Resveratrol can modulate cellular and humoral immunity to reduce pathogen replication and viability, and bidirectionally regulate the production of related cytokines/chemokines through immune response pathways.

4. Cardiovascular and cerebrovascular diseases

As a "blood purifier", resveratrol can not only reduce blood viscosity, restore blood vessel elasticity, but also inhibit platelet coagulation and dilate blood vessels, effectively reduce blood lipid adhesion, prevent thrombosis, improve atherosclerosis, and then prevent cardiovascular and cerebrovascular diseases.

5. Cancer

Resveratrol has a protective effect against a variety of cancers such as colorectal, lung, breast, prostate, ovarian, cervical, liver, and gastric cancers. Resveratrol can prevent the adhesion, migration, and invasion of cancer cells by weakening glycolytic reactions, inhibiting the growth and proliferation of cancer cells, promoting anti-tumor immune responses, and regulating the expression of related molecules and genes through various signaling pathways.

 6. Liver disease

Resveratrol can improve non-alcoholic fatty liver disease, chemical liver injury, fibrosis and cirrhosis by regulating redox reactions, regulating lipid metabolism, reducing inflammation and inducing autophagy of various cytokines, chemokines and transcription factors.

7. Diabetes

Diabetes mellitus is a metabolic chronic disease characterized by high blood sugar. Resveratrol can effectively regulate glucose metabolism, reduce the risk of diabetic complications, and restore normal function of the body by regulating the expression of SIRT1/NF-κB/AMPK signaling pathway and some related molecules (such as NALP3 inflammasome) as well as sRNA.

8. Obesity

According to the Global State of Malnutrition Report released by the Global Alliance for Improved Nutrition, more than 300 million people in China are overweight and obese, and 7% of them are children under the age of five. Resveratrol has been shown to have significant anti-obesity effects by modulating PI3K/SIRT1, Nrf2, PPAR-γ, TNF-α, and PKA/LKB1/AMPK signaling pathways, regulating lipid deposition, and regulating adipocyte gene expression.

9. Alzheimer's disease and Parkinson's disease

Alzheimer's and Parkinson's diseases are neurodegenerative diseases that severely reduce quality of life, and resveratrol may have the potential to improve these conditions. Resveratrol can improve Alzheimer's and Parkinson's disease by activating SIRT1, AMPK, and Nrf2 signaling pathways and regulating related gene expression.

In which plants is resveratrol distributed？

Resveratrol and its derivatives are mainly found in at least 72 species of plants in 21 families and 31 genera such as Vitis vinifera, Polygonum spp., Peanut spp., and Resveratrol, including common medicinal plants such as Japanese knotweed, cassia and mulberry, as well as crops such as grapes and peanuts. The main sources of natural resveratrol are Polygonum cuspidatum and Vitis vinifera.

Polygonum cuspidae is a perennial shrub-like herbaceous plant, mainly distributed in the provinces south of the Yangtze River in China, Hubei, Sichuan and other places. The roots and rhizomes of Polygonum cuspidatum are the main parts of extracting natural resveratrol, which is mainly present in Polygonum cuspidatum plants in the form of Polygonum cuspidatum, the content of resveratrol in plants is very small, and high content of resveratrol can be obtained by biological digestion. Among them, the resveratrol content in the fresh roots of Polygonum cuspidatum was higher than that in the fresh stems, and the resveratrol content in the fresh leaves was almost non-existent.

Grape is a deciduous vine of the Vitis vinifera, which is planted in all parts of the Yangtze River basin in China. The content of resveratrol in wild and artificially cultivated thorn grapes in Hunan, Guizhou and other places is relatively high. The amount of resveratrol in grapes varies from variety to variety, and the content varies from part to part. Resveratrol in grapes is mainly found in vines, skins and seeds, with little or no resveratrol in the pulp.

Resveratrol is a non-flavonoid polyphenol compound that is beneficial to human health, and resveratrol extracted from natural plants cannot meet people's needs for it, so researchers have been committed to researching rapid and safe chemical and biosynthetic methods to obtain resveratrol.　

Where can you find resveratrol?

Natural Field is one of the top supplier of resveratrol in China, and we have been in health and nutrition ingredients industry for 20 years. Welcome to inquiry if you have any demand.

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