Product Information

I. Basic Information

Reduced β-nicotinamide mononucleotide (NMNH) is a nucleotide derivative of great significance in organisms. It is closely related to nicotinamide adenine dinucleotide (NADH) in chemical structure and is one of the direct precursors of NADH. 

In terms of physical properties, it is usually in the form of white to light yellow powder, has certain solubility in water, and shows good stability under specific physiological pH conditions. In organisms, it participates in many crucial metabolic pathways and biochemical reactions and is an important substance for cellular energy metabolism and maintaining redox balance.

II. Comparison with NMN

(I) Differences in chemical structure

The chemical structure of NMN (β-nicotinamide mononucleotide) is slightly but crucially different from that of NMNH. NMN is the oxidized form of nicotinamide mononucleotide, while NMNH is its reduced form. This structural difference leads to differences in their biochemical characteristics and functions.

(II) Comparison of functional characteristics

1. In terms of energy metabolism

• NMN mainly participates in the cellular energy generation process by converting to NAD⁺, especially in energy metabolism pathways related to mitochondria, such as the tricarboxylic acid cycle, providing the energy currency ATP for cells.

• NMNH is more focused on converting to NADH and acting as an important electron donor in the cellular respiratory chain, participating in oxidative phosphorylation and promoting efficient energy generation.

2. In terms of antioxidant effects

• NMN indirectly activates the activity of some antioxidant enzymes by increasing the NAD⁺ level, thereby reducing oxidative stress.

• NMNH itself has stronger reducibility and can directly participate in scavenging free radicals, playing a more direct role in the antioxidant defense system.

  
  

III. Application Fields

(I) Pharmaceutical field

1. Anti-aging research
   Studies have found that as people age, the level of NMNH in the body will decline. Supplementing NMNH may help improve age-related physiological function decline. It can enhance the energy metabolism ability of cells, reduce the accumulation of senescent cells, and has potential preventive and therapeutic effects on some age-related diseases such as cardiovascular diseases and neurodegenerative diseases.

2. Disease treatment
   In some disease states, such as mitochondrial dysfunction-related diseases, including some rare hereditary metabolic diseases, supplementation of NMNH may help restore the normal function of mitochondria and increase the energy supply of cells, thereby alleviating symptoms. At the same time, in oxidative stress-related diseases such as diabetic complications and inflammatory diseases, the antioxidant properties of NMNH can reduce tissue damage.

(II) Health supplement field

As a biologically active substance with potential health benefits, NMNH is widely used in the development of health supplements. It can be used as a nutritional supplement to help people improve their body's antioxidant capacity and energy level. For those who are in a state of fatigue for a long time, have low immunity, or hope to delay aging, health products containing NMNH may be a beneficial choice.

(III) Cosmetics field

The antioxidant property of NMNH makes it a popular choice for cosmetic raw materials. It can be added to skin care products such as creams and essences to help the skin resist the damage of free radicals, reduce the appearance of aging signs such as wrinkles and sagging, and at the same time improve the skin's luster and elasticity and promote the metabolism of skin cells.

IV. Prospect Analysis

(I) Market prospect

With people's increasing attention to health and anti-aging, the market demand for NMNH in fields such as pharmaceuticals, health supplements, and cosmetics is expected to continue to grow. Especially in the high-end health supplement and anti-aging cosmetics markets, NMNH-related products may occupy an important share. According to market research institutions, the market size of NMNH is expected to show a trend of rapid expansion in the next few years.

(II) Scientific research prospect

In scientific research, the study of NMNH is still in a stage of continuous deepening. Scientists will further explore its detailed mechanism of action in cells, including interactions with other metabolic molecules and influences on gene expression. In addition, researchers are also working hard to develop more efficient and safer production methods and administration routes for NMNH to improve its bioavailability and therapeutic effect. At the same time, with the expansion of research on NMNH in different disease models, more potential application fields are expected to be discovered, bringing more benefits to human health.

However, in the development and application process of NMNH, attention should also be paid to safety and quality control issues. Further clinical studies are needed to determine its safety and effectiveness in long-term use to ensure that its application in various fields can truly benefit humanity.

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