The great potential of apigenin in anti-cancer

 What is apigenin?

apigenin is a flavonoid, which is idely distributed in nature. It mainly exists in Periaceae, Verbena, and Selaginaceae plants, and is widely distributed in vegetables and fruits in warm tropics, especially in celery. A large number of studies at home and abroad have found that apigenin has anti-tumor, cardiovascular and cerebrovascular protection, antiviral, antibacterial and other biological activities.

Plant Source

Apigenin is a naturally occurring flavonoid found in various forms in the form of plant yellow, mainly from other plants such as umbrella plants, celery, chamomile, melissa, perilla and whip. It is also found in grass and valerian.



Chamomile is native to the UK and is grown in Germany, France, and Morocco. Roman chamomile and German chamomile have many characteristics in common: about 30 cm high, yellow in the middle, white flowers, and slightly fluffy leaves. Chamomile has the effect of helping sleep, relieving symptoms of inflammation and pain in patients, and relieving insomnia caused by itching of nerves and skin. There are also a large number of medicines and teas grown in China, and the daily sales of herbal teas contain apigenin, which is mainly from mother chrysanthemums and dried chamomiles.

What are its benefits ?

Antioxidant action, anti-tumor action, antibacterial, anti-inflammation, prevention of osteoporosis

How does apigenin fight gastrointestinal cancer?

In the case of gastrointestinal cancer, apigenin was found to induce cell death and impede the growth of new blood vessels that contribute to tumor growth. In addition, apigenin makes the tumor environment more hostile by reducing glucose uptake by cancer cells, interfering with remodeling of the matrix outside and around cancer cells, and blocking processes that promote cancer progression and spread.


Application Of Apigenin In Cosmetics

1. Apigenin can be combined with vitamin B1, vitamin B6, vitamin B12, vitamin C, etc. Can also be combined with plant essential oils such as calendula oil, almond oil, etc. High concentration of apigenin can inhibit the activity of melanocytes, and can be added to sunscreen, face cream, essence, toner, mask and other cosmetics; Can be used in shampoo, conditioner.

2.Apigenin has strong absorption capacity of UVB ultraviolet rays, can protect against radiation damage, and can be used in sunscreen cosmetics. In addition, apigenin can relieve itching on the scalp and can be used in hair care products. Therefore, apigenin is more and more widely used in various functional cosmetics.

Is Apigenin Safe?

Apigenin can effectively improve insomnia. Apigenin is an ingredient in the daily diet, found in a wide variety of vegetables, fruits, and legumes. Lu et al. confirmed through acute and subchronic toxicity experiments and mutagenicity experiments in rats and mice that the polyphenolic extracts of bamboo leaves (the main components
Safe and non-toxic for flavonoids and phenolic acids. Liu Haibo et al. systematically studied the acute toxicity, subchronic toxicity, and genotoxicity of apigenin. The maximum tolerated dose (MTD) of acute toxicity of apigenin in rats is greater than 8 g/kg body weight; the no obvious damage level of apigenin in the 90-day feeding experiment of rats is 8 g/kg body weight; using Ames test, mouse bone marrow microbiology The genotoxicity of apigenin was studied systematically by nuclear experiments and mouse sperm cell deformity experiments, and the results showed no genotoxicity, suggesting the good biological safety of apigenin.