In the Kardashian family’s reality show, Kendall Jenner formed a health bureau and invited Justin Bieber’s wife Hailey Bieber to come to her home for infusion. The infusion was NAD+.
Is nad+, which is highly praised by wealthy people in Europe and the United States and even politicians and entrepreneurs, really so magical?
So, what is Nad+?
NAD+, also called coenzyme I, is a coenzyme present in all living cells. Its full name is nicotinamide adenine dinucleotide. A large amount of experimental data shows that it plays a crucial role in cell metabolism, DNA repair and cell signaling. NAD+ is also involved in other cellular processes such as DNA repair, gene expression, and calcium signaling.
NAD+ research results
Yi L et al. published an article in the journal "Geroscience". The main purpose of this article is to evaluate blood NAD+ concentration and clinical efficacy by taking NAD+ precursor (NMN). Research shows that supplementing with NAD+ precursor (NMN) increases blood NAD+ levels, is safe, and is well tolerated; significantly improves 6-minute walk test scores, blood physiological age, and SF-36 scores in healthy adults. Positive effects on physical endurance and general health.
Pencina KM et al. evaluated the safety and physiological effects of increasing NAD+ levels by oral administration of NAD+ precursors in adults at risk for age-related diseases. Study results show that NAD+ precursors safely increase circulating NAD+ levels and significantly reduce total LDL cholesterol, non-HDL cholesterol, body weight, and diastolic blood pressure in overweight or obese middle-aged and older adults.
NAD+ and glutathione precursors are currently used as metabolic modulators to improve metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative diseases, mitochondrial myopathies, and age-induced diabetes . Therefore, Li Research results show that serine, N-acetylcysteine and L-carnitine tartrate increase NAD+ levels through the NAD+ rescue pathway, and nicotinamide (NAM) taken together with serine, N-acetylcysteine, etc. can further promote NAD+ products, followed by nicotinic acid (NA), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). This result shows that NAD+ precursors can work with serine, N-acetylcysteine, etc. to increase NAD+ levels to improve the body's metabolic status.
Increase NAD+ levels in the body, benefits to the body
Promote material and energy metabolism. Professor Anthony and his research team from the University of California found that nad+ can effectively delay cell aging, thereby extending lifespan.
Replenish and improve muscle endurance
Enhance memory
Enhance metabolism and help control blood sugar
Improve sleep quality. As age increases, people's sleeping patterns will change, increasing nad+ levels will help restore normal sleep.
How to properly supplement nad+
Ingestion from food, such as cabbage, avocado, steak, edamame and other foods contain nad+ precursors, which will be converted into nad+ after absorption by the human body.
Eat a balanced and healthy diet. Many people will find that their energy status is better after they control sugar and low carbs. This is because nad+ consumption is less and nad+ circulation is better.
Keep moving. Moderate exercise will increase intracellular nad+ levels and help improve energy metabolism.
Maintain adequate sleep time. During the sleep process of the human body, cells in the body will perform many repair activities. Adequate sleep will help maintain nad+ levels.
Actively supplement nad+ precursor substances, such as NMN, NR
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[1] Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023;45(1):29-43.
[2] Pencina KM, Valderrabano R, Wipper B, et al. Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. J Clin Endocrinol Metab. 2023;108(8):1968-1980.
[3] Li X, Yang H, Jin H, et al. The acute effect of different NAD+ precursors included in the combined metabolic activators. Free Radic Biol Med. 2023;205:77-89.
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