Product Information

What are co-loaded liposomes

Co-loaded liposomes are a specialized type of liposome structure. Liposomes are artificial membranes consisting mainly of a phospholipid bilayer with an internal aqueous core. Co-loaded liposomes are liposomes that can encapsulate two or more drugs with different properties (e.g., hydrophilic, hydrophobic, etc.) at the same time.

Structural features

The structure still maintains the basic features of liposomes, with vesicles composed of phospholipid bilayers. The size of the vesicles usually ranges from a few tens of nanometers to a few micrometers. The phospholipid bilayer has a hydrophilic head and a hydrophobic tail, and this structure allows liposomes to effectively encapsulate drugs of different properties.

For co-loaded liposomes, multiple drugs can be loaded simultaneously in their internal aqueous phase and in the phospholipid bilayer. For example, hydrophilic drugs can be encapsulated in the internal aqueous phase of the liposome, while hydrophobic drugs can be embedded between the phospholipid bilayers.

Advantages of NFLipo's novel co-loaded liposomes

Synergistic effects:

Co-loading different substances can provide synergistic therapeutic benefits. For example, in tumor therapy, one drug may be mainly used to kill tumor cells, while another drug may be used to inhibit tumor angiogenesis. Co-loading these two drugs in liposomes can fulfill both roles and enhance the therapeutic effect.

Improved drug properties:

Different drugs may have different drawbacks, such as poor solubility and stability. These problems can be improved by co-loading. For example, co-loading a difficult-to-solve drug with a drug with solubilizing effect improves the solubility and bioavailability of the difficult-to-solve drug.

Reduce drug toxicity:

The toxicity associated with the use of high doses of a single drug can be reduced by adjusting the proportion of the co-loaded drug. For example, some chemotherapeutic drugs have high toxicity, co-loading with other drugs that can reduce their toxicity can ensure the therapeutic effect while reducing the damage to normal tissues. We chose natural ginsenosides as the carrier for more significant drug effects.

NFLipo Novel Covalent Liposome A novel liposome (without cholesterol) composed of phospholipids and ginsenosides. This new type of liposome is a “new generation” technology of common liposome, with more advanced preparation, better efficacy and strong synergistic effect of compounding.

       In this new liposome, ginsenoside replaces cholesterol and forms a stable lipid bilayer together with phospholipids, which has better formulation characteristics than the cholesterol-added ordinary liposome and avoids the risk of excessive cholesterol intake.