Product Information

1、 Core advantages of curcumin liposomes

Curcumin, as a natural polyphenolic compound, has biological activities such as anti-inflammatory, antioxidant, and anti-tumor. However, its poor water solubility, low bioavailability, and insufficient stability limit its clinical application. Liposomes, as nanoscale drug carriers, encapsulate curcumin through phospholipid bilayers, significantly improving its water solubility (solubility increased by about 50 times), stability (encapsulation efficiency>85% after 30 days of storage at 4 ℃), and targeted delivery ability, becoming an important strategy for optimizing curcumin formulations.

2、 Common application scenarios

1. Functional foods and health products: increased bioavailability

Nutritional enhancement: Liposome embedding technology solves the limitation of curcumin lipid solubility, develops oral formulations (such as nano liposome capsules), and increases bioavailability by 3-5 times compared to traditional powders. Typical formula: Phospholipids: cholesterol=2:1 (molar ratio), Curcumin: membrane material=1:40 (mass ratio), encapsulation efficiency>90%.

Food additive: Utilizing the stability of liposomes, develop natural pigments that are resistant to light and oxidation for use in beverages and baked goods, replacing synthetic pigments (such as the EU approved E100 curcumin liposomes for dairy products).

2. Cosmetics: Transdermal delivery and skin care enhancement

Anti aging and whitening: Flexible liposomes (such as Pluronic F87 modification) enhance skin permeability, target delivery of curcumin to the dermis layer, inhibit tyrosinase activity, and reduce melanin production. The clinical trial showed that the essence containing 0.5% curcumin liposome could improve the skin brightness by 23% after 28 days of use.

Anti inflammatory repair: pH sensitive liposomes (particle size<200nm) penetrate the stratum corneum, relieve acne and eczema, and reduce irritation. Adding ceramide to the formula can enhance the compatibility between liposomes and the skin.

3. Veterinary drugs and agriculture: green antibacterial applications

Animal Health: Liposome encapsulated curcumin is used as a feed additive for livestock and poultry to improve antibacterial and antiviral effects (such as avian influenza prevention and treatment), and reduce the use of antibiotics.

Crop protection: Nano liposome sustained-release systems (such as chitosan modification) are used for plant disease control, extending the efficacy period (>14 days) and reducing pesticide residues.

3、 Formula Design Guidelines

1. Basic formula composition (mass percentage)

2. Customized formula strategy

Targeted delivery: tumor targeting (TPP+folic acid dual modification), liver targeting (sialic acid glycoprotein modification).

Environmental response: pH sensitive (oleic acid modified, pH 5.5 triggered release), temperature sensitive (DPPC/DSPC mixed membrane, 42 ℃ phase change drug release).

Composite drug delivery: Used in combination with paclitaxel, quinacrine, and other drugs to synergistically enhance efficacy.

3. Key points of preparation process (taking ethanol injection method as an example)

1. Membrane dissolution: Phospholipids, cholesterol, and curcumin are dissolved in chloroform: methanol (2:1) and evaporated by rotary evaporation at 50 ℃ to form a membrane.

2. Hydration dispersion: Hydrate with pH 7.2 phosphate buffer solution (containing 5% sucrose) and sonicate (100W, 10 minutes) to form colostrum.

3. Homogenization optimization: High pressure microfluidics (100MPa, 3 cycles), particle size control 100-150nm.

4. Post treatment: Separation of free drugs by micro column centrifugation, freeze-drying (-50 ℃, 48 hours), encapsulation efficiency>85%.

4. Quality control indicators

Particle size: 100-200nm (DLS detection, PDI＜0.2）

Zeta potential:- 10-20mV (negative charge enhanced stability)

Encapsulation rate:>80% (micro column centrifugation HPLC method)

Release characteristics: 24-hour sustained release>60% in pH 7.4 PBS, 2-hour release<10% in simulated gastric acid (pH 1.2).

5、 Application Case Reference

1. Anti tumor injection: Sunflower lecithin: Cholesterol: DSPE-PEG2000=7: 2: 1 (molar ratio), curcumin: membrane material=1:30, particle size 120nm, encapsulation efficiency 92%, tumor enrichment increased fourfold after intravenous injection (mouse model).

2. Oral health supplements: Sunflower lecithin: cholesterol=3:1, curcumin loading of 5%, freeze-dried formulation with a particle size of 80nm after reconstitution. Human trials have shown that the bioavailability is 5.6 times higher than that of ordinary capsules.

3. Cosmetic essence: flexible liposome (sunflower lecithin: cholesterol: oleic acid=5:3:2), curcumin concentration 0.3%, transdermal rate 0.8 μ g/cm ²/h (Franz diffusion cell test), stability>6 months (stored at 4 ℃).

6、 Future Trends

Intelligent response system: Combining DNA origami and molecular motors (such as ATP synthase) to achieve precise spatiotemporal controlled release.

Biomimetic carrier: Cell membrane (such as red blood cell membrane) disguises liposomes to evade clearance by the reticuloendothelial system and prolong circulation in the body (half-life>24 hours).

Green preparation: Supercritical CO ₂ technology replaces organic solvents, meets GMP requirements, and reduces production costs.

By designing the composition, particle size, and surface modification of liposomes rationally, curcumin liposomes have shown broad prospects in the fields of medicine, food, cosmetics, and more. Xi'an Natural-Field Bio-Technique Co., Ltd.

We will further optimize the large-scale preparation process, conduct long-term toxicity research, promote the transformation from laboratory to industrialization, and fully unleash the potential of this natural active ingredient.