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Application of genistein in antitumor field

Q: What is Genistein?

Genistein is a polyphenolic compound that belongs to the isoflavone family and is found in almost all legumes, including soybeans and coffee beans. Many studies have shown that genistein can relieve inflammation, alter intestinal flora, and improve epithelial barrier function in several animal models of intestinal diseases. In addition, genistein is known to have beneficial effects on age-related diseases such as neurodegenerative and cardiovascular diseases, bone loss, and skin aging.

Souce: It is mainly found in legumes, such as sophora sinensis and mountain bean root.

Q: So what are


 the benefits of Genistein?

1. Genistein and cardiovascular disease

Genistein plays an important role in reducing the incidence of cardiovascular disease. Low density lipoprotein cholesterol in the blood is high and easy to be oxidized, which will cause atherosclerosis. Genistein can effectively reduce cholesterol through antioxidant effect, inhibit the oxidation of low density lipoprotein cholesterol (LDL), and keep LDL in the blood at a low level, improve the abnormal peroxidation status caused by high fat in the body, and alleviate the peroxide damage to the body.
Genistein can also inhibit the proliferation of smooth muscle cells and the formation of blood vessels and inhibit cell adhesion, and reduce the incidence of cardiovascular diseases.

2. Relationship between genistein and cranial nerve

Genistein has the effect of promoting brain nerve regeneration and awakening of brain coma. Modern medical theory believes that a series of pathophysiological changes such as ischemia, hypoxia and necrosis of brain cells are closely related to the influx of calcium ions outside the cells of brain tissue when cerebral infarction occurs. When the route of administration is changed, genistein can cross the blood-brain barrier and protect brain cells when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur by affecting the cell membrane Ca++ receptor.


3. Genistein and cancer

Genistein has inhibitory and therapeutic effects on a variety of cancers through ① antioxidant effect, ② inhibition of tyrosine kinase activity, ③ inhibition of topoisomerase activity, ④ estrogen and anti-estrogen-like effect, and ⑤ reduction of tumor angiogenesis.

4. Genistein and menopausal syndrome in women
Studies have shown that women menopause, due to ovarian degeneration, estrogen reduction in the body, women will appear a series of menopausal symptoms, and the intake of quantitative genistein in menopause can supplement the lack of estrogen in the body, play a role in preventing and reducing women’s menopausal syndrome.

5. Genistein and radiation resistance
The US (AFRRI) laboratory confirmed that it is a radio-protective agent and that genistein significantly improves 30-day survival in mice exposed to a total body irradiation dose (9.5Gy) of fatal traumatic brain injury, regardless of subcutaneous injection 24 hours before irradiation or gavage 4 days before irradiation or 4 days after irradiation.

In the United States, the anti-radiation effect of genistein has been used as a prophylactic and therapeutic product for tumor radiation therapy, and literature has reported that taking genistein before exposure to traumatic brain injury (7.75Gy) can also reduce lung damage in long-term surviving animals.