Apigenin, also known as apigenin or Apigenin, is a naturally occurring flavonoid widely found in many vegetables and fruits, especially celery. In recent years, scientific research has identified the great potential of apigenin in fighting cancer.
Apigenin is considered one of the major flavonoids because it is found in a variety of natural sources, including fruits and vegetables. Dried parsley is the richest source of apigenin, containing 45,035 μg/g.
Agaric
Other sources with high apigenin content are chamomile (dried flowers), celery seed, mulligatawny and Chinese celery, containing 3,000-5,000 μg/ g, 786.5 μg/ g, 622 μg/ g and 240.2 μg/ g, respectively.
Several studies have shown that apigenin has significant anticancer effects and can inhibit the growth and spread of cancer cells through a variety of mechanisms.
apigenin for cancer
How does apigenin treat cancer?
Apigenin is helpful in treating cancer in the following ways:
- Anti-cancer effect: Apigenin is a natural flavonoid with significant anti-cancer activity. Studies have shown that apigenin can inhibit the growth of many kinds of tumor cells, including liver cancer, breast cancer, colon cancer, skin cancer, pancreatic cancer, leukemia cells and so on. It induces apoptosis, i.e., prompts cancer cells to extinguish themselves without damaging normal cells. This selective apoptosis-inducing effect on cancer cells makes apigenin potentially valuable as an anticancer agent.
- Antioxidant effect: Apigenin has an antioxidant effect, which can reduce the growth of oxygen free radicals and inhibit the reaction of lipid oxidation, thus slowing down the aging of human body. The antioxidant effect helps to reduce the oxidative stress that may occur during cancer treatment and has a role in protecting cellular health.
- Anti-inflammatory effects: Apigenin exerts anti-inflammatory effects by inhibiting NO synthase and COX2 enzymes in macrophages, as well as interfering with NF-kb transcription and potentially TNFα-induced upregulation of adhesion molecule 1. Inflammation is closely related to the development and progression of cancer; therefore, the anti-inflammatory effects of apigenin help prevent and treat cancer.
- Prevention of cardiovascular diseases: Apigenin inhibits the growth of vascular smooth muscle cells, thus preventing hypertension, atherosclerosis, and cardiovascular diseases. These diseases are also associated with the development and progression of cancer, so preventing cardiovascular disease can also help reduce the risk of cancer.
So how does apigenin inhibit tumor cells?
Apigenin inhibits tumor growth mainly through the following aspects:
hypertension image from pixabay.com
1.Inhibiting the expression of hypoxia-inducible factor and vascular endothelial growth factor: Apigenin can reduce the expression of hypoxia-inducible factor and vascular endothelial growth factor at the transcriptional level, which helps to inhibit the formation of tumor blood vessels. Blood vessels are key to tumor growth and metastasis; therefore, by inhibiting blood vessel formation, apigenin can effectively inhibit tumor growth and spread.
2.Interfering with tumor cell signaling: Apigenin has the ability to inhibit tyrosine kinases and protein kinases, which play a key role in the signaling process of tumor cells. By altering the binding site of Grb2, the response protein of these kinases, apigenin can inhibit the phosphorylation of MAPK signaling pathway, thus interfering with the signaling of tumor cells and inhibiting their growth and proliferation.
3.Inhibition of oncogene expression and induction of oncogene expression: Apigenin can reduce the phosphorylation level of c-Myc and increase the expression of P53 gene, an important oncogene, which can inhibit the proliferation of tumor cells by inhibiting the expression of oncogenes and up-regulating the expression of oncogenes. Meanwhile, apigenin can further inhibit tumor cell growth by increasing the level of P53 downstream effector P21/waf1 protein.
4.Induction of tumor cell apoptosis: Apigenin can induce tumor cell apoptosis by activating caspase 3 and down-regulating CyclinD1, D3 and Cdk4. Apoptosis is a process of cell self-destruction. By inducing apoptosis of tumor cells, apigenin can effectively reduce the number of tumor cells, thus inhibiting tumor growth.
In summary, apigenin comprehensively inhibits tumor growth and proliferation by inhibiting tumor blood vessel formation, interfering with tumor cell signaling, inhibiting oncogene expression and inducing oncogene expression, as well as inducing apoptosis of tumor cells. This makes apigenin have a broad application prospect in the field of anticancer.
Can Women Take Apigenin?
Yes, women can consume apigenin. Apigenin is a natural compound that works equally well for both men and women. Whether it’s to prevent cancer or to aid in healing, women can benefit from apigenin.
Natural Field’s Apigenin Powder – A New Natural Cancer-Fighting Option
Natural Field has successfully developed a high-quality apigenin powder thanks to its outstanding scientific research and technological innovation. This product has significant advantages in the market:
- Natural and pure: Natural Field’s Apigenin Powder is extracted from pure natural plants without additives and pollution, ensuring that consumers can use it with peace of mind.
- High Activity: After fine processing and purification, Natural Field’s Apigenin Powder has high biological activity, which is able to better fulfill the anti-cancer effect.
- Easily Absorbed: The product adopts a unique formulation process, which makes apigenin easier to be absorbed and utilized by the human body, thus improving the therapeutic effect.
- Convenient to carry: Apigenin powder adopts portable design, which makes it convenient for consumers to use it anytime and anywhere to meet the needs of different scenarios.
Our apigenin powder advantages are:
1.Content stability
2.Our products: 99% 98%
3.Market: 98% 95%
4.Source: Naringin
5.Color: Light yellow (Most of the market is brown and yellow, brown and black)
