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Can fisetin slow down skin aging?

Why are we aging?

The skin is the largest organ of the body and consists mainly of the epidermis, dermis and subcutaneous tissue. As we age, these components gradually deteriorate.

Skin aging is characterized by wrinkles and loss of skin elasticity due to progressive dermal atrophy, which is mainly due to a decrease in the extracellular matrix (ECM), especially collagen.

Accumulated senescent fibroblasts in the skin cause abnormal tissue remodeling and ECM dysfunction through SASP secretion, which leads to collagen degeneration, elastin destruction, inflammatory cell infiltration, fibrotic changes and adipose tissue atrophy. Therefore, removal of senescent cells may be a new therapy to improve skin function.

Foods rich in fisetin

Laclavins are widely found in several common fruits (strawberries, persimmons, apples, grapes, kiwis, peaches) and vegetables (onions, cucumbers).

One of the foods with the highest levels of laccasein is strawberries (160 μg/g strawberries), while the average daily intake for humans is about 0.4 mg.


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Why does fisetin slow down aging?

Fisetin slows down skin ag ing.Fisetin is a natural flavonoid found in a wide range of plants and fruits that possesses a wide range of biological activities and has shown remarkable results especially in anti-aging.

Regarding its specific effects, the main points are as follows:

  1. Antioxidant effect: Fisetin has strong antioxidant capacity, which can scavenge free radicals in the body and reduce oxidative stress, thus protecting skin cells from damage.
  2. Anti-inflammatory effect: By inhibiting the production and release of inflammatory factors, Fisetin can reduce the inflammatory response of the skin and help improve the symptoms of inflammatory skin diseases.
  3. Promoting cellular autophagy: Fisetin can activate the cellular autophagy process, helping to remove damaged or aged organelles and maintain healthy cells.
  4. Anti-aging effect: Through the above mechanism, Fisetin is able to slow down the aging process of the skin, reduce the appearance of wrinkles, discoloration and other signs of aging, and keep the skin in a youthful state.


As for the working principle of Fisetin, it mainly involves the following aspects:

  1. Regulating cell signaling path ways: Fisetin is able to regulate cell signaling pathways related to aging, such as MAPK, PI3K/AKT, etc., thus affecting the process of cell growth, proliferation and apoptosis.
  2. Influence on gene expression: By affecting the expression of certain aging-related genes, Fisetin is able to regulate cellular metabolism and function, thereby slowing down skin aging.
  3. Interacting with other molecules: Fisetin can also interact with some important molecules in the cell, such as proteins and enzymes, and affect their activity and function, thus exerting anti-aging effects.

How to supplement fisetin?

1. Laclavin can be replenished by eating foods rich in laclavin and by taking supplements.

2. Consume dietary supplements, which are made by extracting and concentrating the laccase from plants, to get the right amount of laccase.

Any adverse reactions?

Long-term use of Fisetin may cause some adverse reactions

  1. Gastrointestinal upset: long-term use of Fisetin may cause gastrointestinal upset, such as nausea, vomiting, and diarrhea.
  2. Allergic reaction: Some people may have an allergic reaction to Fisetin, which is manifested by symptoms such as itching, redness and swelling of the skin, and difficulty in breathing.