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Levodopa, the drug of choice for Parkinson’s disease

We all know Parkinson’s disease, Parkinson’s disease is a common middle-aged and elderly neurological degenerative disease, mostly after the age of 60. The main manifestations are slow movement of patients, tremors in the hands and feet or other parts of the body, and the body loses its softness and becomes stiff. The first systematic description of the disease was by the British physician James Mother. Parkinson’s.
The onset of Parkinson’s disease is slow, and the first symptoms often go unnoticed. However, when the following symptoms appear, it can be diagnosed as Parkinson’s disease clinically.

Q: So what does levodopa have to do with this disease?
Levodopa is the most effective treatment for Parkinson’s disease, Levodopa is an antiparalytic. It crosses the blood-brain barrier into brain tissue, where it works. Applicable to various paralytic syndromes.


The mechanism of levodopa in the treatment of Parkinson’s disease:
After taking levodopa, a part of levodopa can cross the blood-brain barrier and be taken up by substantia nigra nerve cells or other nerve cells in the brain to become dopamine, which can supplement dopamine and reduce Parkinson’s symptoms. It usually takes 20-30 minutes to take effect.
Since the cause of Parkinson’s disease is a lack of dopamine, why not just inject or take dopamine?
The answer is that dopamine can’t cross the blood-brain barrier, so it can’t work in the brain.

Q: When is the best time to take levodopa?


It is best to take it on an empty stomach so that the medication can be fully absorbed. Since amino acids produced after digestion of protein in food can affect the absorption of levodopa in multiple links, it should be taken on an empty stomach (1 hour before meals is appropriate). Protein in the diet should be distributed in small amounts and many times evenly.