What is Spermidine?
Spermidine is a type of polyamine widely distributed in organisms, synthesized by butylamine and adenosylmethionine. Spermidine can bind and precipitate DNA, and can also be used to purify DNA binding proteins. On September 1, 2013, scientists from Germany and Austria collaborated to study that it may prevent the onset of Alzheimer’s disease.
Where does spermidine come from?
1. Nutritional supplementation
As mentioned earlier, spermidine exists in almost all living organisms, and animals, plants, and fungi used as food ingredients naturally contain spermidine. Oral intake of spermidine can be quickly absorbed from the intestine and distributed in the body without degradation. Therefore, foods with high levels of spermidine can help increase the level of spermidine. Fungal foods such as wheat germ, cauliflower, soybeans, cheese, natto, and mushrooms are more abundant. We can supplement it through food intake, such as beans, nuts, soybeans, supplements, etc
2. Intestinal Microbial Synthesis
The gut microbiota is an important source of spermidine synthesis, such as the probiotic Bifidobacterium. In addition to synthesizing short chain fatty acids and vitamins, spermidine is also synthesized in the gut.
3 Cell Biosynthesis
In mammals, spermine is converted into spermidine through metabolic energy, and guanine can also synthesize spermidine under the action of enzymes.
What are the effects of spermidine on health?
1.Spermidine has the effect of promoting health and prolonging lifespan.
2. Spermidine can reverse vascular aging and prevent cardiac aging
In elderly mice, it was found that spermidine could reverse atherosclerosis caused by aging by reducing the oxidative damage of vascular endothelial cells. At the same time, spermidine supplementation could also reduce the formation of atherosclerotic plaque caused by high-fat diet.
3 spermidine can avoid metabolic abnormalities
4 spermidine can protect nerves and delay neural decline
It has been found in fruit flies that feeding them with spermidine can improve their autophagic activity, thereby protecting them from the problems of memory decline and motor loss caused by aging.
In addition, other mechanisms of spermidine’s anti-aging potential may include:
1. Antioxidant effect
Oxidative stress is an important factor leading to cell aging and damage. Spermidine also has antioxidant properties, which can help neutralize free radicals and reduce the damage of oxidative stress to cells.
2. DNA stability
Spermidine may help maintain DNA stability, reduce the risk of DNA damage and mutation, which helps prevent cell aging.
3. Regulating cell cycle
Spermidine can also affect cell cycle, helping to maintain normal cell life cycle and reducing the risk of abnormal cell proliferation